Requesting Research Subjects


CSU Research Study

“Volunteers needed for Music Therapy Experience”

Why: The researcher wants to see if using music therapy will improve the ability of people with an acquired brain injury to respond to their environment.

Who: The researcher is looking for males and females (25-65) who have had an acquired brain injury (stroke, traumatic brain injury, tumor removal) with no regular seizures or history of substance abuse. You must be able to understand all directions in English and have functional use of one hand. Additionally, you and someone close to you will fill out a questionnaire. This will help us to see what difficulties you may be experiencing because of your brain injury.

What it involves: If your questionnaires show that you qualify for the study, then you will be randomly placed in one of three groups. All groups will participate in pre-testing and post-testing and these will take place in the Center for Biomedical Research (CBRM) at Colorado State University. Your total time commitment will be approximately 15 hours, spread out over about two months. If you are assigned to one of the music groups, these will take place for one hour, once a week, for five weeks.

When: Fall 2012

Interested? Contact Colleen Mueller, MT-BC by telephone 402-953-7719 or through e-mail: Colleen is a board-certified music therapist and graduate student at CSU. Dr. Blythe LaGasse is the Principal Investigator for this research study. Contact through e-mail: or by telephone (970) 491-4042.


Neuroscience of Rhythm

Our current work in the neuroscience of rhythm perception and rhythmic synchronization mechanisms has produced results in 3 major areas:

1)    Empirical data and computational modeling of how the brain synchronizes rhythmic movement to external rhythm;

2)    Evidence for subliminal perception of auditory timing information below the level of conscious perception, which the brain nevertheless uses to guide the timing of rhythmic movement;

3)    Brain mapping using PET-scanning technology to describe neural networks involved in rhythmic synchronization.

In conjunction with groups in Germany (Duesseldorf University: Department of Neurology and Neurological Therapy Center; Federal Research Center Juelich)and Italy (IRCCS Santa Lucia and IESS-CNR, Rome) we were recently able to map the cortical and subcortical areas in the brain, involving parieto-thalamic, cerebellar, and frontal networks, that are active and contribute to the process of auditory rhythm perception and rhythmic motor synchronization. These studies into brain function also revealed the different neuroanatomical areas active during different levels of perceptual awareness and consciousness in the brain when processing external sensory information. The different levels of human consciousness appear to be linked to differential activation patterns in the prefrontal cortex. We showed how even subliminal auditory timing information is processed in the auditory cortex and translated into precise changes in the timing of movement without cognitive awareness and learning. We recently developed a data driven model, which models mathematically the strong and fast physiological attractor or 'magnet' function of auditory rhythm to influence the timing of movement. All these studies, employing neurophysiological data recording such as Positron Emission Tomography and Magnetic and Electric Encephalography, contributed new knowledge to the study of sensorimotor integration in the brain, the role of perception in action, and how the brain perceives and produces rhythm.


Neurologic Rehabilitation

The area of neurologic rehabilitation our research findings have focused on 3 areas:

1)    The application of rhythmic entrainment to facilitate and improve the long-term gait ability of patients with stroke, Parkinson's disease, cerebral palsy, and traumatic brain injury;

2)    First evidence that rhythmic stimulation might also work in the rehabilitation of arm functions;

3)    Data and computational models of the mechanisms showing why auditory rhythm stabilizes and optimizes movement kinematics in therapeutic training.

Our group (associate faculty, postdoctoral fellows, graduate students from neurology, physical and music therapy, biomechanics, mathematics, electrical engineering, physics) discovered in first experiments in 1990 that the strong synchronization effect of rhythm on gait movements has a profound facilitating effect on the gait ability of stroke patients. Research experiments synchronizing gait patterns to auditory rhythm led to dramatic gait improvements in speed, symmetry, and muscle activation patterns in patients whose gait ability was severely compromised. Further rehabilitation studies have shown by now that rhythmic training can also produce sustainable improvements in gait recovery over longer periods of time. Since then, other patient groups have been successfully researched as well, most notably patients with Parkinson's disease, traumatic brain injury, and cerebral palsy. Most recent studies show that the use of the upper extremities can also be improved with rhythmically patterned movement training. This research has been introduced at numerous international medical and rehabilitation conferences, and is being practiced at several large rehabilitation centers in the U.S. Also, several hundred patients from our community have gone through research and clinical studies at the CBRM labs, documenting how scientific research can be integrated into community outreach essential to the university's mission. At the 1999 World Congress of Neurologic Rehabilitation, the rhythmic model of rehabilitative motor training developed in our lab was recognized as one of 6 current evidence-based motor training techniques.


Neurologic Music Therapy

Our research has facilitated the development of Neurologic Music Therapy as a new, research based treatment system for patients with neurologic disorders. Neurologic Music Therapy is based on utilizing the physiological mechanisms inherent in music perception and production. Treatment techniques are standardized for functional therapeutic outcomes.